Review

The Anorexia Nervosa Brain: A Summary of Neuroimaging Studies – Part 1

Tetyana 1 Comment

Journalists like to report on novel and exciting findings regardless of how likely they are to be replicated or how well they fit with everything else known about the topic. It is an all too common occurrence that a small pilot study which has favourable results, creates a buzz and gets into our heads, only to produce negative results once the sample size is increased. But the latter, negative finding, rarely makes it to the printing press. So, we are left thinking the results of the pilot study are correct, when they might be an outlier or a false positive.

Given this, I wanted to summarize an article that provides a critical overview of the current neuroimaging studies in anorexia nervosa. We can use this as an introduction to neuroimaging in AN: to get a sense of the scientific consensus, the trends that emerge and what can be learned from … Continue reading →

When Clinicians Do More Harm Than Good (Attitudes Toward Patients with Eating Disorders)

Tetyana 33 Comments

I was going to blog more about mortality rates in eating disorder patients, but recent ED-related deaths have left a bitter taste in my mouth (huge understatement). So, I’ve decided instead to write about a paper requested by the founder of The Joy Project on clinician reactions to patients with eating disorders by Thomspon-Brenner and colleagues that came out this year.

If you have an eating disorder or are close to someone with an eating disorder, you’ve likely heard many stories about dismissive or down-right negative and harmful attitudes that clinicians often have toward patients with EDs.

I’ve experienced it myself: I had to find another doctor to refer me to an outpatient clinic, because the first one didn’t – he didn’t think I needed help (probably because I was very aware that things were not heading in the right direction even before I was at a low weight). Needless … Continue reading →

Etiology of Eating Disorders: A Model of "Empirical Structure"

Saren 1 Comment

Hello all, Saren here. I’m honored that Tetyana asked me to be her co-contributor to ScienceofEDs, and am looking forward to collaborating on the project. My interests and background tend more towards the clinical; I don’t have the neuroscience training that she does, so I hope to bring a slightly different perspective while remaining committed to the research focus of the site. I can be reached at saren[@]scienceofeds[.]org with any questions, critiques or suggestions – I’d love to hear from you!

For my first post, I’m going to focus on one of the basic areas that much of the recent ED research aims to address:

WHAT CAUSES EATING DISORDERS?

We hear a lot about how eating disorders are complex syndromes with multiple causes. Articles in the popular press run the gamut from asserting genetic risk factors to proclaiming that Facebook causes eating disorders. In addition, disordered eating practices and poor … Continue reading →

A Meta-Analysis of Mortality in Eating Disorders

Tetyana

You often hear that anorexia nervosa has the highest mortality rate of any psychiatric illness, but you might struggle to find the rates for bulimia nervosa or EDNOS. Even for AN, the most common cause of death is rarely reported and the reported rates often vary a lot (depending on the study (and the media outlet).

I wanted to find out what are: (1) the mortality rates in BN and EDNOS and (2) the common causes of death in these disorders.  A relatively recent meta-analysis (click here for some background, pros and cons of meta-analyses) of 36 studies, which addressed some of my questions, was published by Arcelus and colleagues.

They excluded studies that had less than 15 patients and/or <1-year follow-up.

SO, WHAT DID THEY FIND?

Mortality in Anorexia Nervosa:

  • 35 studies, mean follow-up time: 12.8 years (maximum 36.2), mean sample size was 361 (maximum 6009).
  • Total
… Continue reading →

More on the Problematic EDNOS Category (and Diagnostic Crossover)

Tetyana 2 Comments

I’ve been thinking a lot lately about the eating disorder not otherwise specified (EDNOS) category. ED-NOS is a diagnostic category for all individuals with subthreshold anorexia or bulimia nervosa or those with a mix of symptoms that don’t fit neatly into AN or BN. ED-NOS is essentially everything else. A mixed bag, if you will. It doesn’t tell the clinician nor the researcher anything useful, outside of what it isn’t. So, is there any use for it? If it doesn’t tell the clinician about patient symptoms or guide choice of treatment, why even bother? Does it help researchers understand EDs or do they just want to avoid this messy and heterogenous group (that by the way makes up most of those with eating disorders)? In this entry (and many more to come), I want to further explore these questions.

There’s been a push by researchers to minimize the … Continue reading →

The Genetics of Anorexia Nervosa

Tetyana 11 Comments

Is it the culture of thinness, obsession with dieting or just bad mothering? When it comes to determining the causes of anorexia nervosa, the answer appears to be none of the above. Increasingly, the evidence is pointing to genetics playing an important role in predisposing individuals to anorexia nervosa. Among clinicians and researchers, the notion that genetic factors are important in the development of anorexia nervosa seems uncontested. In this short review, Dr. Cynthia Bulik and colleagues summarize some of the findings in the genetics of anorexia nervosa.

Currently (DSM-IV), to be diagnosed with anorexia nervosa, a patient must show:

  • An inability to maintain normal weight (<85% of what is expected)
  • Intense fear of weight gain and/or becoming fat, though underweight
  • Obsession with body weight and shape, giving it undue importance in evaluating self-esteem/self-worth
  • Amenorrhea (missing 3 or more consecutive periods)
  • There are two AN-subtypes: restricting type (AN-R) and
… Continue reading →